ea0029oc3.1 | Diabetes Clinical | ICEECE2012
Bonetti S.
, Trombetta M.
, Linda B.
, Dauriz M.
, Malerba G.
, Trabetti E.
, Pignatti P.
, Bonora E.
, Bonadonna R.
We tested the hypothesis that common genetic variability of β cell mass and/or function genes may influence β cell functional mass in type 2 diabetes (T2DM). We studied 590 drug-naive GAD-negative patients with newly diagnosed T2DM (age: median=60.0 yrs; I.Q. range: 5266; BMI: 29.3 kg/m2; 26.532.9). β cell functional mass was assessed by state-of-art mathematical modeling of glucose/C-peptide curves during a 240 frequently sampled O...